2026 NFL Week 1 Odds Released: Full Spreads & Schedule

The 2026 NFL regular season ignites on Wednesday, September 9, marking a historic shift from traditional Thursday openers, with full Week 1 betting odds now released across all 16 matchups. Fans and bettors are dissecting spreads for a slate that includes a Super Bowl LX rematch and the NFL’s inaugural regular-season game in Australia.

The 2026 NFL season breaks tradition, starting on a Wednesday. The opening spectacle features a highly anticipated Super Bowl LX rematch between the reigning champion Seattle Seahawks and the New England Patriots at Lumen Field in Seattle. Kickoff is set for 8:20 p.m. ET on NBC and Peacock, with DraftKings installing the Seahawks as -3.5 favorites (-180 moneyline) over the Patriots (+150). SportsLine's model projects Seattle to cover this spread, potentially winning by a touchdown.

Global expansion takes center stage on Thursday, September 10, as the San Francisco 49ers face the Los Angeles Rams at the Melbourne Cricket Ground in Melbourne, Australia. This landmark game, streaming exclusively on Netflix, kicks off at 8:35 p.m. ET (Friday, 10:35 a.m. AEST local time). The Rams, bolstered by the return of Aaron Donald and the acquisition of Myles Garrett, are favored at -3.5 (-198 moneyline) against the 49ers (+164), with a total of 48.5, according to DraftKings. Doc's Sports predicts the 49ers will cover the spread in this matchup.

Beyond the marquee openers, Week 1 presents a full slate of compelling matchups and early betting opportunities. The Los Angeles Chargers stand as the largest spread favorite, opening at -10.5 against the Arizona Cardinals. In other notable Sunday games, the New Orleans Saints visit the Detroit Lions, with the Lions favored by -7, while the Baltimore Ravens are -3.5 favorites at the Indianapolis Colts.

The Jacksonville Jaguars are projected to cover their -7.5 spread against the Cleveland Browns in nearly 60% of SportsLine's simulations. Meanwhile, the Philadelphia Eagles, favored by -5.5 against the Washington Commanders, are also predicted by SportsLine to cover in nearly 60% of simulations, with a projected final score of 27-18. Sunday night features an NFC East clash at MetLife Stadium, where the Dallas Cowboys are -2.5 favorites against the New York Giants.

Week 1 concludes on Monday, September 14, with an AFC West showdown: the Denver Broncos at the Kansas City Chiefs at GEHA Field at Arrowhead Stadium (ESPN, ABC, ESPN2, 8:15 p.m. ET). SportsBettingDime lists the Chiefs as -3.0 favorites (+100) against the Broncos (+120), with a total of 42.5. This game marks the anticipated return of Patrick Mahomes from a season-ending knee injury, a key storyline for the Chiefs.

The initial release of Week 1 odds provides a crucial early barometer for the season ahead. Bettors are already reacting to significant player developments, such as Aaron Donald's return and Myles Garrett's move to the Rams, which heavily influence futures markets. As John Harbaugh takes the helm for the Giants, the team is a "significant Super Bowl liability" at DraftKings and Fanatics, indicating high public confidence.

The dynamic nature of betting lines means further adjustments are expected as injuries, transactions, and public money shift. With rookies like Jadarian Price expected to carry the load for the Seahawks' backfield and the Patriots' offense potentially boosted by AJ Brown and Drake Maye's mobility, Week 1 offers a compelling, albeit challenging, start to the NFL calendar.